|Other Names||Methionine-R-sulfoxide reductase B3, MsrB3, 184-, MSRB3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13112a was selected from the N-term region of MSRB3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing.|
|Cellular Location||Isoform 1: Endoplasmic reticulum.|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene catalyzes the reductionof methionine sulfoxide to methionine. This enzyme acts as amonomer and requires zinc as a cofactor. Several transcriptvariants encoding two different isoforms have been found for thisgene. One of the isoforms localizes to mitochondria while the otherlocalizes to endoplasmic reticula.
Pillas, D., et al. PLoS Genet. 6 (2), E1000856 (2010) :Kwak, G.H., et al. BMB Rep 42(9):580-585(2009)Taungjaruwinai, W.M., et al. Am J Dermatopathol 31(5):427-431(2009)Lamesch, P., et al. Genomics 89(3):307-315(2007)Fortna, A., et al. PLoS Biol. 2 (7), E207 (2004) :
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