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GP2 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P55259 |
|---|---|
| Clone Names | 100324081 |
| Gene ID | 2813 |
|---|---|
| Other Names | Pancreatic secretory granule membrane major glycoprotein GP2, Pancreatic zymogen granule membrane protein GP-2, ZAP75, GP2 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13123a was selected from the N-term region of GP2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GP2 (HGNC:4441) |
|---|---|
| Function | Functions as an intestinal M-cell transcytotic receptor specific for type-I-piliated bacteria that participates in the mucosal immune response toward these bacteria. At the apical membrane of M- cells it binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typhimurium, from the lumen of the intestine and delivers them, through M-cells, to the underlying organized lymphoid follicles where they are captured by antigen-presenting dendritic cells to elicit a mucosal immune response. |
| Cellular Location | Zymogen granule membrane {ECO:0000250|UniProtKB:P19218}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P19218}. Secreted Cell membrane {ECO:0000250|UniProtKB:P19218}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P19218}. Apical cell membrane {ECO:0000250|UniProtKB:Q9D733}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P19218}. Membrane raft {ECO:0000250|UniProtKB:P19218}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P19218}. Endosome {ECO:0000250|UniProtKB:Q9D733}. Note=Secreted, after cleavage, in the pancreatic juice. |
| Tissue Location | Expressed in pancreas (at protein level) (PubMed:8666297, PubMed:10760606). Specifically expressed by M (microfold) cells which are atypical epithelial cells of the intestine (at protein level) (PubMed:19907495). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The specific function of this protein remains unknown.
References
Kottgen, A., et al. Nat. Genet. 42(5):376-384(2010)Masson, E., et al. Pancreas 39(3):353-358(2010)Witt, H., et al. Pancreas 39(2):188-192(2010)Boulling, A., et al. Mol. Genet. Metab. 99(3):319-324(2010)Hase, K., et al. Nature 462(7270):226-230(2009)
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