|Other Names||Long-chain specific acyl-CoA dehydrogenase, mitochondrial, LCAD, ACADL|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13134a was selected from the N-term region of ACADL. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Mitochondrion matrix.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to the acyl-CoAdehydrogenase family, which is a family of mitochondrialflavoenzymes involved in fatty acid and branched chain amino-acidmetabolism. This protein is one of the four enzymes that catalyzethe initial step of mitochondrial beta-oxidation of straight-chainfatty acid. Defects in this gene are the cause of long-chainacyl-CoA dehydrogenase (LCAD) deficiency, leading to nonketotichypoglycemia.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Maher, A.C., et al. Mol. Genet. Metab. 100(2):163-167(2010)Illig, T., et al. Nat. Genet. 42(2):137-141(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Lu, Y., et al. J. Lipid Res. 49(12):2582-2589(2008)
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