|Other Names||Solute carrier organic anion transporter family member 3A1, OATP3A1, Organic anion transporter polypeptide-related protein 3, OATP-RP3, OATPRP3, Organic anion-transporting polypeptide D, OATP-D, PGE1 transporter, Sodium-independent organic anion transporter D, Solute carrier family 21 member 11, SLCO3A1, OATP3A1, OATPD, SLC21A11|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13144c was selected from the Center region of SLCO3A1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||OATP3A1, OATPD, SLC21A11|
|Function||Mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate (PubMed:10873595). Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin, but not DPDPE (a derivative of enkephalin lacking an N-terminal tyrosine residue), estrone-3- sulfate, taurocholate, digoxin nor DHEAS (PubMed:16971491).|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Ubiquitous. Highly expressed in spleen and leukocytes. Generally the expression of isoform 1 is higher than that of isoform 2. Isoform 2 is particularly abundant in testis and brain. In testis, isoform 1 is detected in spermatogonia at different stages and absent from Sertoli cells, while isoform 2 is present in both (at protein level). Expressed in the choroid plexus epithelium, isoform 1 being localized at the basolateral membrane and isoform 2 at the apical one, as well as in the subapical intracellular vesicular compartments. Differential expression of both isoforms is also observed in other brain region: isoform 1 is very abundant in the gray matter of the frontal cortex, but is not associated with neuronal cell bodies Not detected in the white matter. In contrast, isoform 2 is associated with neuronal bodies and axons in both the gray and the white matters of the frontal cortex|
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SLCO3A1 mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate (PubMed:10873595). Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin, but not DPDPE (a derivative of enkephalin lacking an N-terminal tyrosine residue), estrone-3-sulfate, taurocholate, digoxin nor DHEAS (PubMed:16971491).
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Volpi, S., et al. Mol. Psychiatry 14(11):1024-1031(2009)Montasser, M.E., et al. J. Hypertens. 27(3):491-501(2009)Lasky-Su, J., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (8), 1345-1354 (2008) :Huber, R.D., et al. Am. J. Physiol., Cell Physiol. 292 (2), C795-C806 (2007) :
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