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SLCO3A1 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9UIG8
Clone Names 100405126
Peptide ID 100405126
Additional Information
Gene ID 28232
Other Names Solute carrier organic anion transporter family member 3A1, OATP3A1, Organic anion transporter polypeptide-related protein 3, OATP-RP3, OATPRP3, Organic anion-transporting polypeptide D, OATP-D, PGE1 transporter, Sodium-independent organic anion transporter D, Solute carrier family 21 member 11, SLCO3A1, OATP3A1, OATPD, SLC21A11
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13144c was selected from the Center region of SLCO3A1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLCO3A1
Synonyms OATP3A1, OATPD, SLC21A11
Function Mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate (PubMed:10873595). Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin, but not DPDPE (a derivative of enkephalin lacking an N-terminal tyrosine residue), estrone-3- sulfate, taurocholate, digoxin nor DHEAS (PubMed:16971491).
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location Ubiquitous. Highly expressed in spleen and leukocytes. Generally the expression of isoform 1 is higher than that of isoform 2. Isoform 2 is particularly abundant in testis and brain. In testis, isoform 1 is detected in spermatogonia at different stages and absent from Sertoli cells, while isoform 2 is present in both (at protein level). Expressed in the choroid plexus epithelium, isoform 1 being localized at the basolateral membrane and isoform 2 at the apical one, as well as in the subapical intracellular vesicular compartments. Differential expression of both isoforms is also observed in other brain region: isoform 1 is very abundant in the gray matter of the frontal cortex, but is not associated with neuronal cell bodies Not detected in the white matter. In contrast, isoform 2 is associated with neuronal bodies and axons in both the gray and the white matters of the frontal cortex
Research Areas
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Background

SLCO3A1 mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate (PubMed:10873595). Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin, but not DPDPE (a derivative of enkephalin lacking an N-terminal tyrosine residue), estrone-3-sulfate, taurocholate, digoxin nor DHEAS (PubMed:16971491).

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Volpi, S., et al. Mol. Psychiatry 14(11):1024-1031(2009)Montasser, M.E., et al. J. Hypertens. 27(3):491-501(2009)Lasky-Su, J., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (8), 1345-1354 (2008) :Huber, R.D., et al. Am. J. Physiol., Cell Physiol. 292 (2), C795-C806 (2007) :

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$ 80.00
Cat# BP13144c
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