|Other Names||Arylamine N-acetyltransferase 1, Arylamide acetylase 1, Monomorphic arylamine N-acetyltransferase, MNAT, N-acetyltransferase type 1, NAT-1, NAT1, AAC1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13168c was selected from the center region of NAT1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.|
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Provided below are standard protocols that you may find useful for product applications.
This gene is one of two arylamine N-acetyltransferase(NAT) genes in the human geneome, and is orthologous to the mouseand rat Nat2 genes. The enzyme encoded by this gene catalyzes thetransfer of an acetyl group from acetyl-CoA to various arylamineand hydrazine substrates. This enzyme helps metabolize drugs andother xenobiotics, and functions in folate catabolism. Multipletranscript variants encoding different isoforms have been found forthis gene.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Minchin, R.F., et al. Int. J. Biochem. Cell Biol. 39(11):1999-2005(2007)Barker, D.F., et al. Pharmacogenet. Genomics 16(7):515-525(2006)Boukouvala, S., et al. Basic Clin. Pharmacol. Toxicol. 96(5):343-351(2005)
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