|Other Names||Solute carrier family 26 member 9, Anion transporter/exchanger protein 9, SLC26A9|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13193a was selected from the N-term region of SLC26A9. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport. Mediates chloride/bicarbonate exchange or chloride-independent bicarbonate extrusion thus assuring bicarbonate secretion. Inhibited by ammonium and thiosulfate.|
|Cellular Location||Membrane; Multi-pass membrane protein|
|Tissue Location||Predominantly expressed in lung at the luminal side of the bronchiolar and alveolar epithelium of lung. To a lower extent, also expressed in pancreas and prostate|
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Provided below are standard protocols that you may find useful for product applications.
This gene is one member of a family of sulfate/aniontransporter genes. Family members are well conserved in theirgenomic (number and size of exons) and protein (aa length amongspecies) structures yet have markedly different tissue expressionpatterns. The product of this gene is a highly selective chlorideion channel regulated by WNK kinases. Alternative splicing resultsin multiple transcript variants encoding differing isoforms.
Mosbruger, T.L., et al. J. Infect. Dis. 201(9):1371-1380(2010)Chang, M.H., et al. J. Biol. Chem. 284(41):28306-28318(2009)Bertrand, C.A., et al. J. Gen. Physiol. 133(4):421-438(2009)Loriol, C., et al. Cell. Physiol. Biochem. 22 (1-4), 15-30 (2008) :Dorwart, M.R., et al. J. Physiol. (Lond.) 584 (PT 1), 333-345 (2007) :
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