|Other Names||Rod cGMP-specific 3', 5'-cyclic phosphodiesterase subunit alpha, GMP-PDE alpha, PDE V-B1, PDE6A, PDEA|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13220c was selected from the Center region of PDE6A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||This protein participates in processes of transmission and amplification of the visual signal.|
|Cellular Location||Cell membrane; Lipid-anchor; Cytoplasmic side|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes the cyclic-GMP (cGMP)-specificphosphodiesterase 6A alpha subunit, expressed in cells of theretinal rod outer segment. The phosphodiesterase 6 holoenzyme is aheterotrimer composed of an alpha, beta, and two gamma subunits.cGMP is an important regulator of rod cell membrane current, andits dynamic concentration is established by phosphodiesterase 6AcGMP hydrolysis and guanylate cyclase cGMP synthesis. The proteinis a subunit of a key phototransduction enzyme and participates inprocesses of transmission and amplification of the visual signal.Mutations in this gene have been identified as one cause ofautosomal recessive retinitis pigmentosa.
Clark, G.R., et al. Ophthalmology 117(11):2169-2177(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Perlis, R.H., et al. Biol. Psychiatry 67(11):1110-1113(2010)Bazhin, A.V., et al. Cell. Mol. Life Sci. 67(5):817-828(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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