|Other Names||GTPase IMAP family member 8, Immune-associated nucleotide-binding protein 9, IAN-9, Protein IanT, GIMAP8, IAN9, IANT|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13234a was selected from the N-term region of GIMAP8. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections.|
|Cellular Location||Endoplasmic reticulum. Golgi apparatus. Mitochondrion. Cytoplasm, cytosol|
|Tissue Location||Expressed in the spleen, intestine, liver, and colon, as well as in lung, placenta, kidney, muscle, and heart Extremely low expression, if any, in brain, in thymus, bone marrow, and blood leukocytes (PubMed:15474311). Detected in T- cells (PubMed:23454188).|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein belonging to the GTP-bindingsuperfamily and to the immuno-associated nucleotide (IAN) subfamilyof nucleotide-binding proteins. In humans, the IAN subfamily genesare located in a cluster at 7q36.1.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Davila, S., et al. Genes Immun. 11(3):232-238(2010)Dion, C., et al. Int. Immunol. 17(9):1257-1268(2005)Krucken, J., et al. Gene 341, 291-304 (2004) :Cambot, M., et al. Blood 99(9):3293-3301(2002)
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