|Other Names||Ankyrin repeat and SOCS box protein 4, ASB-4, ASB4|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13246b was selected from the C-term region of ASB4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of theankyrin repeat and SOCS box-containing (ASB) family of proteins.They contain ankyrin repeat sequence and SOCS box domain. The SOCSbox serves to couple suppressor of cytokine signalling (SOCS)proteins and their binding partners with the elongin B and Ccomplex, possibly targeting them for degradation. Multiplealternatively spliced transcript variants have been described forthis gene but some of the full length sequences are not known.
Li, J.Y., et al. J. Neuroendocrinol. 17(6):394-404(2005)Kile, B.T., et al. Trends Biochem. Sci. 27(5):235-241(2002)Kile, B.T., et al. Gene 258 (1-2), 31-41 (2000) :
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