|Other Names||Transmembrane protein 203, TMEM203|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13264b was selected from the C-term region of TMEM203. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the regulation of cellular calcium homeotasis (PubMed:25996873). Required for spermatogenesis (PubMed:25996873).|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein EMBL; CH471090; EAW88365.1; -; Genomic_DNA EMBL; BC009283; AAH09283.1; -; mRNA EMBL; BC009461; AAH09461.1; -; mRNA EMBL; BC067786; AAH67786.1; -; mRNA CCDS; CCDS35185.1; - RefSeq; NP_444273.1; NM_053045.1 UniGene; Hs.231029; - ProteinModelPortal; Q969S6; - BioGrid; 125117; 2 IntAct; Q969S6; 1 STRING; 9606.ENSP00000375053; - TCDB; 8.A.76.1.1; the tmem203 or pf14967 (tmem203) family BioMuta; TMEM203; - DMDM; 74731059; - PaxDb; Q969S6; - PRIDE; Q969S6; - Ensembl; ENST00000343666; ENSP00000375053; ENSG00000187713 GeneID; 94107; - KEGG; hsa:94107; - UCSC; uc004clv.4; human CTD; 94107; - GeneCards; TMEM203; - HGNC; HGNC:28217; TMEM203 HPA; HPA043250; - MIM; 616499; gene neXtProt; NX_Q969S6; - OpenTargets; ENSG00000187713; - PharmGKB; PA162406377; - eggNOG; ENOG410IY4R; Eukaryota eggNOG; ENOG4111SGD; LUCA GeneTree; ENSGT00510000049510; - HOGENOM; HOG000007895; - HOVERGEN; HBG059488; - InParanoid; Q969S6; - OMA; FEIWINL; - OrthoDB; EOG091G0UU5; - PhylomeDB; Q969S6; - TreeFam; TF323514; - BioCyc; ZFISH:G66-33717-MONOMER; - GenomeRNAi; 94107; - PRO; PR:Q969S6; - Proteomes; UP000005640; Chromosome 9 Bgee; ENSG00000187713; - CleanEx; HS_TMEM203; - Genevisible; Q969S6; HS GO; GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO; GO:0006874; P:cellular calcium ion homeostasis; IDA:UniProtKB GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB InterPro; IPR019396; TM_Fragile-X-F-assoc Pfam; PF10269; Tmemb_185A; 1 1: Evidence at protein level; Complete proteome; Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane; Transmembrane helix CHAIN 1 136 Transmembrane protein 203 /FTId=PRO_0000317203 TRANSMEM 14 34 Helical. TRANSMEM 50 72 Helical. TRANSMEM 81 101 Helical. TRANSMEM 112 132 Helical. CONFLICT 96 96 V -> F (in Ref. 2; AAH67786) SEQUENCE 136 AA; 15760 MW; 87CA7D87F00B16FC CRC64; MLFSLRELVQ WLGFATFEIF VHLLALLVFS VLLALRVDGL VPGLSWWNVF VPFFAADGLS TYFTTIVSVR LFQDGEKRLA VLRLFWVLTV LSLKFVFEML LCQKLAEQTR ELWFGLITSP LFILLQLLMI RACRVN|
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Provided below are standard protocols that you may find useful for product applications.
The specific function of this protein remains unknown.
Strausberg, R.L., et al. Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903(2002)
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