TRIM62 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9BVG3 |
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Clone Names | 100408348 |
Gene ID | 55223 |
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Other Names | E3 ubiquitin-protein ligase TRIM62, 632-, Tripartite motif-containing protein 62, TRIM62 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13293b was selected from the C-term region of TRIM62. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TRIM62 {ECO:0000303|PubMed:23402750, ECO:0000312|HGNC:HGNC:25574} |
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Function | E3 ubiquitin ligase that plays a role in antifungal immunity by mediating 'Lys-27'-linked ubiquitination of CARD9 downstream of C- type lectin receptors; leading to CARD9 activation, followed by activation of NF-kappa-B and MAP kinase p38 pathways (PubMed:26488816). E3 ubiquitin ligase activity is dependent on E2 ubiquitin-conjugating enzyme UBE2D2 (PubMed:23402750). |
Cellular Location | Cytoplasm |
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Provided below are standard protocols that you may find useful for product applications.
Background
The specific function of this protein remains unknown.
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :Lott, S.T., et al. PLoS Med. 6 (5), E1000068 (2009) :Muthuswamy, S.K. PLoS Med. 6 (5), E1000073 (2009) :Colland, F., et al. Genome Res. 14(7):1324-1332(2004)
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