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NKG2D Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P26718
Clone Names 100408363
Peptide ID 100408363
Additional Information
Gene ID 100528032;22914
Other Names NKG2-D type II integral membrane protein, Killer cell lectin-like receptor subfamily K member 1, NK cell receptor D, NKG2-D-activating NK receptor, CD314, KLRK1, D12S2489E, NKG2D
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13295a was selected from the N-term region of NKG2D. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name KLRK1
Synonyms D12S2489E, NKG2D
Function Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4.
Cellular Location Cell membrane; Single- pass type II membrane protein Note=Colocalized with HCST on the cell surface
Tissue Location Expressed in natural killer (NK) cells, CD8(+) alpha-beta and gamma-delta T-cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC. Expressed in interferon-producing killer dendritic cells (IKDCs)
Research Areas
Citations (0)

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Natural killer (NK) cells are lymphocytes that can mediatelysis of certain tumor cells and virus-infected cells withoutprevious activation. They can also regulate specific humoral andcell-mediated immunity. NK cells preferentially express severalcalcium-dependent (C-type) lectins, which have been implicated inthe regulation of NK cell function. This gene encodes a member ofthe NKG2 family, and the encoded transmembrane protein ischaracterized by a type II membrane orientation (extracellular Cterminus) and the presence of a C-type lectin domain. The NKG2 genefamily is located within the NK complex, a region that containsseveral C-type lectin genes preferentially expressed in NK cells.


Hanaoka, N., et al. J. Immunol. 185(10):5732-5742(2010)Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)Ma, J., et al. J. Med. Virol. 82(9):1501-1507(2010)Champsaur, M., et al. J. Immunol. 185(1):157-165(2010)Campbell, J.A., et al. J. Immunol. 185(1):28-32(2010)

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$ 80.00
Cat# BP13295a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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