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NKG2D Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P26718 |
|---|---|
| Clone Names | 100408363 |
| Gene ID | 100528032;22914 |
|---|---|
| Other Names | NKG2-D type II integral membrane protein, Killer cell lectin-like receptor subfamily K member 1, NK cell receptor D, NKG2-D-activating NK receptor, CD314, KLRK1, D12S2489E, NKG2D |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13295a was selected from the N-term region of NKG2D. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | KLRK1 |
|---|---|
| Synonyms | D12S2489E, NKG2D |
| Function | Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress- inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell- mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. |
| Cellular Location | Cell membrane; Single-pass type II membrane protein Note=Colocalized with HCST on the cell surface |
| Tissue Location | Expressed in natural killer (NK) cells, CD8(+) alpha-beta and gamma-delta T-cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC. Expressed in interferon- producing killer dendritic cells (IKDCs). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Natural killer (NK) cells are lymphocytes that can mediatelysis of certain tumor cells and virus-infected cells withoutprevious activation. They can also regulate specific humoral andcell-mediated immunity. NK cells preferentially express severalcalcium-dependent (C-type) lectins, which have been implicated inthe regulation of NK cell function. This gene encodes a member ofthe NKG2 family, and the encoded transmembrane protein ischaracterized by a type II membrane orientation (extracellular Cterminus) and the presence of a C-type lectin domain. The NKG2 genefamily is located within the NK complex, a region that containsseveral C-type lectin genes preferentially expressed in NK cells.
References
Hanaoka, N., et al. J. Immunol. 185(10):5732-5742(2010)Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)Ma, J., et al. J. Med. Virol. 82(9):1501-1507(2010)Champsaur, M., et al. J. Immunol. 185(1):157-165(2010)Campbell, J.A., et al. J. Immunol. 185(1):28-32(2010)
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