|Other Names||Calpain small subunit 1, CSS1, Calcium-activated neutral proteinase small subunit, CANP small subunit, Calcium-dependent protease small subunit, CDPS, Calcium-dependent protease small subunit 1, Calpain regulatory subunit, CAPNS1, CAPN4, CAPNS|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13301a was selected from the N-term region of CAPNS1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulatory subunit of the calcium-regulated non- lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.|
|Cellular Location||Cytoplasm. Cell membrane. Note=Translocates to the plasma membrane upon calcium binding.|
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Provided below are standard protocols that you may find useful for product applications.
Calpains are a ubiquitous, well-conserved family ofcalcium-dependent, cysteine proteases. Calpain families have beenimplicated in neurodegenerative processes, as their activation canbe triggered by calcium influx and oxidative stress. Calpain I andII are heterodimeric with distinct large subunits associated withcommon small subunits, all of which are encoded by different genes.This gene encodes a small subunit common to both calpain I and IIand is associated with myotonic dystrophy. Two transcript variantsencoding the same protein have been identified for this gene.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Zhang, F., et al. J. Med. Virol. 82(6):920-928(2010)Demarchi, F., et al. Cell Cycle 9(4):755-760(2010)Fairfax, B.P., et al. Hum. Mol. Genet. 19(4):720-730(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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