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CAPNS1 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P04632 |
|---|---|
| Clone Names | 100409008 |
| Gene ID | 826 |
|---|---|
| Other Names | Calpain small subunit 1, CSS1, Calcium-activated neutral proteinase small subunit, CANP small subunit, Calcium-dependent protease small subunit, CDPS, Calcium-dependent protease small subunit 1, Calpain regulatory subunit, CAPNS1, CAPN4, CAPNS |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13301a was selected from the N-term region of CAPNS1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CAPNS1 |
|---|---|
| Synonyms | CAPN4, CAPNS |
| Function | Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Essential for embryonic development (By similarity). |
| Cellular Location | Cytoplasm. Cell membrane. Note=Translocates to the plasma membrane upon calcium binding. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Calpains are a ubiquitous, well-conserved family ofcalcium-dependent, cysteine proteases. Calpain families have beenimplicated in neurodegenerative processes, as their activation canbe triggered by calcium influx and oxidative stress. Calpain I andII are heterodimeric with distinct large subunits associated withcommon small subunits, all of which are encoded by different genes.This gene encodes a small subunit common to both calpain I and IIand is associated with myotonic dystrophy. Two transcript variantsencoding the same protein have been identified for this gene.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Zhang, F., et al. J. Med. Virol. 82(6):920-928(2010)Demarchi, F., et al. Cell Cycle 9(4):755-760(2010)Fairfax, B.P., et al. Hum. Mol. Genet. 19(4):720-730(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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