|Other Names||Battenin, Batten disease protein, Protein CLN3, CLN3, BTS|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13304c was selected from the Center region of CLN3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes.|
|Cellular Location||Lysosome membrane; Multi- pass membrane protein. Late endosome. Lysosome|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that is involved in lysosomalfunction. Mutations in this, as well as other neuronalceroid-lipofuscinosis (CLN) genes, cause neurodegenerative diseasescommonly known as Batten disease or collectively known as neuronalceroid lipofuscinoses (NCLs). Many alternatively spliced transcriptvariants have been found for this gene.
Adams, H.R., et al. Dev Med Child Neurol 52(7):637-643(2010)Imielinski, M., et al. Nat. Genet. 41(12):1335-1340(2009)Sarpong, A., et al. Clin. Genet. 76(1):38-45(2009)Codlin, S., et al. J. Cell. Sci. 122 (PT 8), 1163-1173 (2009) :Tuxworth, R.I., et al. Hum. Mol. Genet. 18(4):667-678(2009)
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