|Other Names||Threonine aspartase 1, Taspase-1, 3425-, Threonine aspartase subunit alpha, Threonine aspartase subunit beta, TASP1, C20orf13|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1330b was selected from the C-term region of human TASP1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Protease involved in KMT2A/MLL1 processing and, consequently, in the correct expression of the early HOXA gene cluster.|
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Provided below are standard protocols that you may find useful for product applications.
TASP1 is an endopeptidase that cleaves specific substrates following aspartate residues. The encoded protein undergoes posttranslational autoproteolytic processing to generate alpha and beta subunits, which reassemble into the active alpha2-beta2 heterotetramer. It is required to cleave MLL, a protein required for the maintenance of HOX gene expression, and TFIIA, a basal transcription factor.
Hsieh, J.J., et al., Cell 115(3):293-303 (2003).
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