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HtrA1 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q92743
Clone Names 2100401
Peptide ID 2100401
Additional Information
Gene ID 5654
Other Names Serine protease HTRA1, 3421-, High-temperature requirement A serine peptidase 1, L56, Serine protease 11, HTRA1, HTRA, PRSS11
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1331b was selected from the C-term region of human HtrA1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name HTRA1
Synonyms HTRA, PRSS11
Function Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.
Cellular Location Secreted. Cytoplasm, cytosol. Note=Predominantly secreted. Also found associated with the plasma membrane
Tissue Location Widely expressed, with strongest expression in placenta (at protein level). Secreted by synovial fibroblasts. Up- regulated in osteoarthritis and rheumatoid arthritis synovial fluids and cartilage as compared with non-arthritic (at protein level).
Research Areas
Citations (0)

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HtrA1 is a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth.


Howes, N., et al., Clin Gastroenterol Hepatol 2(3):252-261 (2004).Chien, J., et al., Oncogene 23(8):1636-1644 (2004).Hu, S.I., et al., J. Biol. Chem. 273(51):34406-34412 (1998).Zumbrunn, J., et al., Genomics 45(2):461-462 (1997).Zumbrunn, J., et al., FEBS Lett. 398 (2-3), 187-192 (1996).

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$ 80.00
Cat# BP1331b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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