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ROBLD3 Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q9Y2Q5
Clone Names 100416161
Peptide ID 100416161
Additional Information
Gene ID 28956
Other Names Ragulator complex protein LAMTOR2, Endosomal adaptor protein p14, Late endosomal/lysosomal Mp1-interacting protein, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2, Mitogen-activated protein-binding protein-interacting protein, MAPBP-interacting protein, Roadblock domain-containing protein 3, LAMTOR2, MAPBPIP, ROBLD3
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13338c was selected from the Center region of ROBLD3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
Cellular Location Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side
Research Areas
Citations (0)

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The product of this gene is highly conserved with a mouseprotein associated with the cytoplasmic face of late endosomes andlysosomes. The mouse protein interacts with MAPK scaffold protein1, a component of the mitogen-activated protein kinase pathway. Inhumans, a mutation in this gene has been associated with a primaryimmunodeficiency syndrome, and suggests a role for this protein inendosomal biogenesis. Multiple transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].


Sancak, Y., et al. Cell 141(2):290-303(2010)Wunderlich, W., et al. J. Cell Biol. 152(4):765-776(2001)

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$ 80.00
Cat# BP13338c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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