|Other Names||Transmembrane gamma-carboxyglutamic acid protein 1, Proline-rich gamma-carboxyglutamic acid protein 1, Proline-rich Gla protein 1, PRRG1, PRGP1, TMG1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13343a was selected from the N-term region of PRRG1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Highly expressed in the spinal cord.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a vitamin K-dependent,gamma-carboxyglutamic acid (Gla)-containing, single-passtransmembrane protein. This protein contains a Gla domain at theN-terminus, preceded by a propeptide sequence required forpost-translational gamma-carboxylation of specific glutamic acidresidues by a vitamin K-dependent gamma-carboxylase. The C-terminusis proline-rich containing PPXY and PXXP motifs found in a varietyof signaling and cytoskeletal proteins. This gene is highlyexpressed in the spinal cord. Several alternatively splicedtranscript variants have been found for this gene. [provided byRefSeq].
Lamesch, P., et al. Genomics 89(3):307-315(2007)Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)Ross, M.T., et al. Nature 434(7031):325-337(2005)Kulman, J.D., et al. Proc. Natl. Acad. Sci. U.S.A. 94(17):9058-9062(1997)
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