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PRRG1 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O14668 |
|---|---|
| Clone Names | 100416175 |
| Gene ID | 5638 |
|---|---|
| Other Names | Transmembrane gamma-carboxyglutamic acid protein 1, Proline-rich gamma-carboxyglutamic acid protein 1, Proline-rich Gla protein 1, PRRG1, PRGP1, TMG1 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13343a was selected from the N-term region of PRRG1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PRRG1 |
|---|---|
| Synonyms | PRGP1, TMG1 |
| Cellular Location | Membrane; Single-pass type I membrane protein |
| Tissue Location | Highly expressed in the spinal cord. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a vitamin K-dependent,gamma-carboxyglutamic acid (Gla)-containing, single-passtransmembrane protein. This protein contains a Gla domain at theN-terminus, preceded by a propeptide sequence required forpost-translational gamma-carboxylation of specific glutamic acidresidues by a vitamin K-dependent gamma-carboxylase. The C-terminusis proline-rich containing PPXY and PXXP motifs found in a varietyof signaling and cytoskeletal proteins. This gene is highlyexpressed in the spinal cord. Several alternatively splicedtranscript variants have been found for this gene. [provided byRefSeq].
References
Lamesch, P., et al. Genomics 89(3):307-315(2007)Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)Ross, M.T., et al. Nature 434(7031):325-337(2005)Kulman, J.D., et al. Proc. Natl. Acad. Sci. U.S.A. 94(17):9058-9062(1997)
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