|Other Names||E3 ubiquitin-protein ligase RNF213, 632-, ALK lymphoma oligomerization partner on chromosome 17, Mysterin, RING finger protein 213, RNF213, ALO17, C17orf27, KIAA1554, KIAA1618, MYSTR|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13344c was selected from the Center region of KIAA1618. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin-protein ligase involved in angiogenesis (PubMed:21799892, PubMed:26278786, PubMed:26766444, PubMed:26126547). Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression (PubMed:26766444). Also has ATPase activity (PubMed:24658080, PubMed:26126547).|
|Cellular Location||Cytoplasm, cytosol|
|Tissue Location||Widely expressed (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
There are three isoforms. A chromosomal aberration involving KIAA1618 is associated with anaplastic large-cell lymphoma (ALCL). Translocation t(2;17)(p23;q25) with ALK.
Choudhary, C., et al. Science 325(5942):834-840(2009)Dephoure, N., et al. Proc. Natl. Acad. Sci. U.S.A. 105(31):10762-10767(2008)Han, G., et al. Proteomics 8(7):1346-1361(2008)Imami, K., et al. Anal Sci 24(1):161-166(2008)Bechtel, S., et al. BMC Genomics 8, 399 (2007) :
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