|Other Names||Coiled-coil domain-containing protein 120, CCDC120|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13363a was selected from the N-term region of CCDC120. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Required for neurite growth. Localizes CYTH2 to vesicles to allow its transport along neurites, and subsequent ARF6 activation and neurite growth.|
|Cellular Location||Cytoplasm. Cell projection. Cell projection, growth cone. Endosome. Note=In differentiating neuroblastoma cells, colocalizes with CYTH2 in both neurite shaft and growth cone areas. Partially colocalizes with endosomes along neurites in differentiating neuroblastoma cells|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that contains a coiled-coildomain. Four alternatively spliced transcript variants that encodedifferent protein isoforms have been described for this gene.
Xin, X., et al. Genome Res. 19(7):1262-1269(2009)Tarpey, P.S., et al. Nat. Genet. 41(5):535-543(2009)Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
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