CCDC120 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q96HB5 |
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Clone Names | 100422019 |
Gene ID | 90060 |
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Other Names | Coiled-coil domain-containing protein 120, CCDC120 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13363a was selected from the N-term region of CCDC120. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | CCDC120 |
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Function | Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC68, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092). Recruits NIN and CEP170 to centrosomes (PubMed:28422092). Also required for neurite growth. Localizes CYTH2 to vesicles to allow its transport along neurites, and subsequent ARF6 activation and neurite growth. |
Cellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm. Cell projection, neuron projection. Cell projection, growth cone. Endosome Note=Localizes to the subdistal appendages of mother centrioles and proximal ends of both centrioles in interphase cells (PubMed:28422092) Recruited to subdistal appendages by ODF2 (PubMed:28422092). In differentiating neuroblastoma cells, colocalizes with CYTH2 in both neurite shaft and growth cone areas (PubMed:25326380). Partially colocalizes with endosomes along neurites in differentiating neuroblastoma cells (PubMed:25326380). |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein that contains a coiled-coildomain. Four alternatively spliced transcript variants that encodedifferent protein isoforms have been described for this gene.
References
Xin, X., et al. Genome Res. 19(7):1262-1269(2009)Tarpey, P.S., et al. Nat. Genet. 41(5):535-543(2009)Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
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