|Other Names||Transforming growth factor-beta receptor-associated protein 1, TGF-beta receptor-associated protein 1, TRAP-1, TRAP1, TGFBRAP1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13395b was selected from the C-term region of TGFBRAP1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2.|
|Cellular Location||Cytoplasm. Early endosome. Note=Colocalizes with TGF-beta receptors in the absence of signaling|
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Provided below are standard protocols that you may find useful for product applications.
TGFBRAP1 plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2.
Rose, J. Phd, et al. Mol. Med. (2010) In press :Le Clerc, S., et al. J. Infect. Dis. 200(8):1194-1201(2009)Hwang, Y., et al. Pharmacogenomics 7(5):697-709(2006)Wurthner, J.U., et al. J. Biol. Chem. 276(22):19495-19502(2001)Provost, P., et al. Proc. Natl. Acad. Sci. U.S.A. 96(5):1881-1885(1999)
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