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TGFBRAP1 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8WUH2 |
|---|---|
| Clone Names | 100406247 |
| Gene ID | 9392 |
|---|---|
| Other Names | Transforming growth factor-beta receptor-associated protein 1, TGF-beta receptor-associated protein 1, TRAP-1, TRAP1, TGFBRAP1 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13395b was selected from the C-term region of TGFBRAP1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TGFBRAP1 |
|---|---|
| Function | Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2. |
| Cellular Location | Cytoplasm. Early endosome. Note=Colocalizes with TGF-beta receptors in the absence of signaling |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
TGFBRAP1 plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2.
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :Le Clerc, S., et al. J. Infect. Dis. 200(8):1194-1201(2009)Hwang, Y., et al. Pharmacogenomics 7(5):697-709(2006)Wurthner, J.U., et al. J. Biol. Chem. 276(22):19495-19502(2001)Provost, P., et al. Proc. Natl. Acad. Sci. U.S.A. 96(5):1881-1885(1999)
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