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SHOX Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O15266 |
|---|---|
| Clone Names | 90713235 |
| Gene ID | 6473 |
|---|---|
| Other Names | Short stature homeobox protein, Pseudoautosomal homeobox-containing osteogenic protein, Short stature homeobox-containing protein, SHOX, PHOG |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13401b was selected from the C-term region of SHOX. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SHOX |
|---|---|
| Synonyms | PHOG |
| Function | Controls fundamental aspects of growth and development. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00138} |
| Tissue Location | SHOXA is expressed in skeletal muscle, placenta, pancreas, heart and bone marrow fibroblast and SHOXB is highly expressed in bone marrow fibroblast followed by kidney and skeletal muscle. SHOXB is not expressed in brain, kidney, liver and lung. Highly expressed in osteogenic cells |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene belongs to the paired homeobox family and islocated in the pseudoautosomal region 1 (PAR1) of X and Ychromosomes. Defects in this gene are associated with idiopathicgrowth retardation and in the short stature phenotype of Turnersyndrome patients. This gene is highly conserved across speciesfrom mammals to fish to flies. Alternatively spliced transcriptvariants encoding different isoforms have been noted for this gene.
References
Barroso, E., et al. Eur J Med Genet 53(4):204-207(2010)D'haene, B., et al. J. Clin. Endocrinol. Metab. 95(6):3010-3018(2010)Durand, C., et al. Eur. J. Hum. Genet. 18(5):527-532(2010)Chen, J., et al. J. Med. Genet. 46(12):834-839(2009)Gahunia, H.K., et al. Semin Musculoskelet Radiol 13(3):236-254(2009)
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