|Other Names||Tomoregulin-1, TR-1, H7365, Transmembrane protein with EGF-like and one follistatin-like domain, TMEFF1, C9orf2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13412b was selected from the C-term region of TMEFF1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May inhibit NODAL and BMP signaling during neural patterning (By similarity). May be a tumor suppressor in brain cancers.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed predominantly in brain, and at lower levels in heart, placenta and skeletal muscle. Down-regulated in brain tumors as compared to control brain tissues|
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Provided below are standard protocols that you may find useful for product applications.
TMEFF1 may inhibit NODAL and BMP signaling during neural patterning (By similarity). May be a tumor suppressor in brain cancers.
Letra, A., et al. Am. J. Med. Genet. A 152A (7), 1701-1710 (2010) :Harms, P.W., et al. Genes Dev. 17(21):2624-2629(2003)Gery, S., et al. Oncogene 22(18):2723-2727(2003)Eib, D.W., et al. Cytogenet. Cell Genet. 81 (3-4), 180-181 (1998) :Eib, D.W., et al. J. Neurochem. 67(3):1047-1055(1996)
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