|Other Names||Endogenous retrovirus group 3 member 1 Env polyprotein, ERV-3 envelope protein, ERV3 envelope protein, ERV3-1 envelope protein, Envelope polyprotein, HERV-R envelope protein, ERV-R envelope protein, HERV-R_7q212 provirus ancestral Env polyprotein, Surface protein, SU, Transmembrane protein, TM, ERV3-1, ERV3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13435b was selected from the C-term region of ERV3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its fusogenic properties. It can inhibit cell growth through decrease expression of cyclin B1 and increased expression of p21 in vitro.|
|Tissue Location||Expressed at higher level in adrenal, sebaceous glands and placenta. Expressed at lower level in bone marrow, brain, breast, colon, heart, kidney, liver, lung, ovary, PBL, prostate, skin, spleen, testis, thymus, thyroid, trachea|
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Provided below are standard protocols that you may find useful for product applications.
The human genome includes many retroelements including thehuman endogenous retroviruses (HERVs). ERV3, one of the moststudied HERVs, is thought to have integrated 30 to 40 million yearsago and is present in higher primates with the exception ofgorillas. Taken together, the observation of genome conservation,the detection of transcript expression, and the presence ofconserved ORFs is circumstantial evidence for a functional role. Afunctional role is also suggested by the observation thatdownregulation of ERV3 is reported in choriocarcinoma. [provided byRefSeq].
Andersson, A.C., et al. J. Virol. 79(14):9270-9284(2005)Herve, C.A., et al. Genomics 83(5):940-943(2004)Blaise, S., et al. Proc. Natl. Acad. Sci. U.S.A. 100(22):13013-13018(2003)de Parseval, N., et al. J. Virol. 77(19):10414-10422(2003)Andersson, A.C., et al. Virology 297(2):220-225(2002)
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