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C10orf58 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9BRX8 |
|---|---|
| Clone Names | 100405109 |
| Gene ID | 84293 |
|---|---|
| Other Names | Redox-regulatory protein FAM213A, Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes, Protein PAMM, FAM213A, C10orf58, PAMM |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13446b was selected from the C-term region of C10orf58. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PRXL2A (HGNC:28651) |
|---|---|
| Function | Involved in redox regulation of the cell (PubMed:26438880, PubMed:19951071). Acts as an antioxidant (PubMed:19951071, PubMed:26438880). Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation (PubMed:19951071). May affect bone resorption and help to maintain bone mass (PubMed:19951071). Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway (PubMed:26438880). |
| Cellular Location | Cytoplasm. Secreted. Note=Secreted from mature adipocytes but not from preadipocytes. |
| Tissue Location | Expressed in CSF1 and TNFSF11-stimulated CD14(+) peripheral blood mononuclear cells (PBMCs) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The specific function of the protein remains unknown.
References
Castellano, S., et al. EMBO Rep. 5(1):71-77(2004)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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