|Other Names||Protein patched homolog 2, PTC2, PTCH2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13460a was selected from the N-term region of PTCH2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH).|
|Cellular Location||Membrane; Multi-pass membrane protein.|
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This gene encodes a transmembrane receptor of the patchedgene family. The encoded protein may function as a tumor suppressorin the hedgehog signaling pathway. Alterations in this gene havebeen associated with nevoid basal cell carcinoma syndrome, basalcell carcinoma, medulloblastoma, and susceptibility to congenitalmacrostomia. Alternatively spliced transcript variants have beendescribed.
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Fan, Z., et al. Am. J. Med. Genet. A 149A (3), 521-524 (2009) :Li, T.J., et al. Beijing Da Xue Xue Bao 41(1):16-20(2009)Fan, Z., et al. J. Med. Genet. 45(5):303-308(2008)Rahnama, F., et al. Biochem. J. 378 (PT 2), 325-334 (2004) :
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