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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   D4S234E Antibody (N-term) Blocking peptide   

D4S234E Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P42857
Clone Names 100416126
Peptide ID 100416126
Additional Information
Gene ID 27065
Other Names Neuron-specific protein family member 1, Brain neuron cytoplasmic protein 1, NSG1, D4S234
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13496a was selected from the N-term region of D4S234E. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NSG1 (HGNC:18790)
Function Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse (By similarity). Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome (By similarity). In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage (PubMed:20599942, PubMed:20878061).
Cellular Location Membrane {ECO:0000250|UniProtKB:P02683}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P02683}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:P02683}. Endosome membrane {ECO:0000250|UniProtKB:P02683}. Cell projection, dendrite {ECO:0000250|UniProtKB:P02683}. Early endosome membrane {ECO:0000250|UniProtKB:P02683}. Late endosome membrane {ECO:0000250|UniProtKB:P02683}. Lysosome lumen {ECO:0000250|UniProtKB:P02683}. Recycling endosome membrane {ECO:0000250|UniProtKB:P02683}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P02683}. Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:P02683}. Endosome, multivesicular body membrane {ECO:0000250|UniProtKB:P02683}. Endoplasmic reticulum membrane. Note=Endocytosed from the cell surface, thus enters into early endosomes, trafficks to late endosomes and degradates in lysosomes (By similarity) Endoplasmic reticulum targeting is essential for apoptosis (PubMed:20599942). Found in both stationary and motile endosomes A previous study supports a type I membrane protein topology (By similarity). {ECO:0000250|UniProtKB:P02683, ECO:0000250|UniProtKB:Q62092, ECO:0000269|PubMed:20599942}
Research Areas
Citations (0)

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Background

The specific function of the protein remains unknown.

References

Kudoh, T., et al. Exp. Cell Res. 316(17):2849-2858(2010)Steiner, P., et al. J. Cell Biol. 157(7):1197-1209(2002)Carlock, L., et al. Brain Res. Mol. Brain Res. 42(2):202-212(1996)

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$ 80.00
Cat# BP13496a
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