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HNRNPH2 Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P55795
Clone Names 100324013
Additional Information
Gene ID 3188
Other Names Heterogeneous nuclear ribonucleoprotein H2, hnRNP H2, FTP-3, Heterogeneous nuclear ribonucleoprotein H', hnRNP H', Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed, HNRNPH2, FTP3, HNRPH2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13497b was selected from the C-term region of HNRNPH2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name HNRNPH2
Synonyms FTP3, HNRPH2
Function This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG).
Cellular Location Nucleus, nucleoplasm
Tissue Location Expressed ubiquitously.
Research Areas
Citations (0)
citation

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Background

This gene belongs to the subfamily of ubiquitouslyexpressed heterogeneous nuclear ribonucleoproteins (hnRNPs). ThehnRNPs are RNA binding proteins and they complex with heterogeneousnuclear RNA (hnRNA). These proteins are associated with pre-mRNAsin the nucleus and appear to influence pre-mRNA processing andother aspects of mRNA metabolism and transport. While all of thehnRNPs are present in the nucleus some seem to shuttle between thenucleus and the cytoplasm. The hnRNP proteins have distinct nucleicacid binding properties. The protein encoded by this gene has threerepeats of quasi-RRM domains that binds to RNAs. It is very similarto the family member HNRPH1. This gene is thought to be involved inFabray disease and X-linked agammaglobulinemia phenotype.Alternative splicing results in multiple transcript variantsencoding the same protein.

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Maggi, L.B. Jr., et al. Mol. Cell. Biol. 28(23):7050-7065(2008)Miyasaka, T., et al. Cancer Sci. 99(4):755-761(2008)Olsen, J.V., et al. Cell 127(3):635-648(2006)

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$ 277.78
Cat# BP13497b
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Availability: 2 weeks
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