|Other Names||Heterogeneous nuclear ribonucleoprotein H2, hnRNP H2, FTP-3, Heterogeneous nuclear ribonucleoprotein H', hnRNP H', Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed, HNRNPH2, FTP3, HNRPH2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13497b was selected from the C-term region of HNRNPH2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG).|
|Cellular Location||Nucleus, nucleoplasm.|
|Tissue Location||Expressed ubiquitously.|
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This gene belongs to the subfamily of ubiquitouslyexpressed heterogeneous nuclear ribonucleoproteins (hnRNPs). ThehnRNPs are RNA binding proteins and they complex with heterogeneousnuclear RNA (hnRNA). These proteins are associated with pre-mRNAsin the nucleus and appear to influence pre-mRNA processing andother aspects of mRNA metabolism and transport. While all of thehnRNPs are present in the nucleus some seem to shuttle between thenucleus and the cytoplasm. The hnRNP proteins have distinct nucleicacid binding properties. The protein encoded by this gene has threerepeats of quasi-RRM domains that binds to RNAs. It is very similarto the family member HNRPH1. This gene is thought to be involved inFabray disease and X-linked agammaglobulinemia phenotype.Alternative splicing results in multiple transcript variantsencoding the same protein.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Maggi, L.B. Jr., et al. Mol. Cell. Biol. 28(23):7050-7065(2008)Miyasaka, T., et al. Cancer Sci. 99(4):755-761(2008)Olsen, J.V., et al. Cell 127(3):635-648(2006)
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