|Other Names||PHD finger-like domain-containing protein 5A, PHD finger-like domain protein 5A, Splicing factor 3B-associated 14 kDa protein, SF3b14b, PHF5A|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13500b was selected from the C-term region of PHF5A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a transcriptional regulator by binding to the GJA1/Cx43 promoter and enhancing its up-regulation by ESR1/ER- alpha. Also involved in pre-mRNA splicing.|
|Cellular Location||Nucleus. Nucleus speckle|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a subunit of the splicing factor 3bprotein complex. Splicing factor 3b, together with splicing factor3a and a 12S RNA unit, forms the U2 small nuclearribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3acomplex binds pre-mRNA upstream of the intron's branch site in asequence-independent manner and may anchor the U2 snRNP to thepre-mRNA. The protein encoded by this gene contains aPHD-finger-like domain that is flanked by highly basic N- andC-termini. This protein belongs to the PHD-finger superfamily andmay act as a chromatin-associated protein. This gene has severalpseudogenes on different chromosomes.
Kuwasako, K., et al. Proteins 71(4):1617-1636(2008)Will, C.L., et al. RNA 10(6):929-941(2004)Collins, J.E., et al. Genome Biol. 5 (10), R84 (2004) :Will, C.L., et al. EMBO J. 21(18):4978-4988(2002)Zhou, Z., et al. Nature 419(6903):182-185(2002)
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