|Other Names||Tubulin alpha-4A chain, Alpha-tubulin 1, Testis-specific alpha-tubulin, Tubulin H2-alpha, Tubulin alpha-1 chain, TUBA4A, TUBA1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13535b was selected from the C-term region of TUBA4A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.|
|Cellular Location||Cytoplasm, cytoskeleton.|
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Provided below are standard protocols that you may find useful for product applications.
Microtubules of the eukaryotic cytoskeleton performessential and diverse functions and are composed of a heterodimerof alpha and beta tubulin. The genes encoding these microtubuleconstituents are part of the tubulin superfamily, which is composedof six distinct families. Genes from the alpha, beta and gammatubulin families are found in all eukaryotes. The alpha and betatubulins represent the major components of microtubules, whilegamma tubulin plays a critical role in the nucleation ofmicrotubule assembly. There are multiple alpha and beta tubulingenes and they are highly conserved among and between species. Thisgene encodes an alpha tubulin that is a highly conserved homolog ofa rat testis-specific alpha tubulin.
Houck, S.A., et al. PLoS ONE 5 (7), E11795 (2010) :Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :Gudbjartsson, D.F., et al. Nat. Genet. 40(5):609-615(2008)Petretti, C., et al. EMBO Rep. 7(4):418-424(2006)Fiore, G., et al. Neurosci. Lett. 394(1):57-62(2006)
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