|Other Names||Mucolipin-1, MG-2, Mucolipidin, MCOLN1, ML4|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13551b was selected from the C-term region of MCOLN1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cation channel probably playing a role in the endocytic pathway and in the control of membrane trafficking of proteins and lipids. Could play a major role in Ca(2+) transport regulating lysosomal exocytosis.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein|
|Tissue Location||Widely expressed in adult and fetal tissues.|
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This gene encodes a memberof the transient receptorpotential (TRP) cation channel gene family. The transmembraneprotein localizes to intracellular vesicular membranes includinglysosomes, and functions in the late endocytic pathway and in theregulation of lysosomal exocytosis. The channel is permeable toCa(2+), Fe(2+), Na(+), K(+), and H(+), and is modulated by changesin Ca(2+) concentration. Mutations in this gene result inmucolipidosis type IV.
Eichelsdoerfer, J.L., et al. J. Biol. Chem. 285(45):34304-34308(2010)Curcio-Morelli, C., et al. J. Cell. Physiol. 222(2):328-335(2010)Vergarajauregui, S., et al. J. Biol. Chem. 284(52):36357-36366(2009)Ballif, B.A., et al. Mol. Cell Proteomics 3(11):1093-1101(2004)LaPlante, J.M., et al. FEBS Lett. 532 (1-2), 183-187 (2002) :
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