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ALPPL2 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P10696 |
|---|---|
| Clone Names | 100427295 |
| Gene ID | 251 |
|---|---|
| Other Names | Alkaline phosphatase, placental-like, ALP-1, Alkaline phosphatase Nagao isozyme, Germ cell alkaline phosphatase, GCAP, Placental alkaline phosphatase-like, PLAP-like, ALPPL2, ALPPL |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13552a was selected from the N-term region of ALPPL2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ALPG (HGNC:441) |
|---|---|
| Function | Alkaline phosphatase that can hydrolyze various phosphate compounds. |
| Cellular Location | Cell membrane; Lipid-anchor, GPI-anchor. |
| Tissue Location | Trace amounts in the testis and thymus, and in elevated amounts in germ cell tumors |
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Provided below are standard protocols that you may find useful for product applications.
Background
There are at least four distinct but related alkalinephosphatases: intestinal, placental, placental-like, andliver/bone/kidney (tissue non-specific). The product of this geneis a membrane bound glycosylated enzyme, localized to testis,thymus and certain germ cell tumors, that is closely related toboth the placental and intestinal forms of alkaline phosphatase.
References
Pelttari, K., et al. Arthritis Rheum. 54(10):3254-3266(2006)Nakano, T., et al. Biochem. Biophys. Res. Commun. 341(1):33-38(2006)Hillier, L.W., et al. Nature 434(7034):724-731(2005)Le Du, M.H., et al. J. Biol. Chem. 277(51):49808-49814(2002)Kozlenkov, A., et al. J. Biol. Chem. 277(25):22992-22999(2002)
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