|Other Names||Alkaline phosphatase, placental-like, ALP-1, Alkaline phosphatase Nagao isozyme, Germ cell alkaline phosphatase, GCAP, Placental alkaline phosphatase-like, PLAP-like, ALPPL2, ALPPL|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13552a was selected from the N-term region of ALPPL2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor.|
|Tissue Location||Trace amounts in the testis and thymus, and in elevated amounts in germ cell tumors|
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Provided below are standard protocols that you may find useful for product applications.
There are at least four distinct but related alkalinephosphatases: intestinal, placental, placental-like, andliver/bone/kidney (tissue non-specific). The product of this geneis a membrane bound glycosylated enzyme, localized to testis,thymus and certain germ cell tumors, that is closely related toboth the placental and intestinal forms of alkaline phosphatase.
Pelttari, K., et al. Arthritis Rheum. 54(10):3254-3266(2006)Nakano, T., et al. Biochem. Biophys. Res. Commun. 341(1):33-38(2006)Hillier, L.W., et al. Nature 434(7034):724-731(2005)Le Du, M.H., et al. J. Biol. Chem. 277(51):49808-49814(2002)Kozlenkov, A., et al. J. Biol. Chem. 277(25):22992-22999(2002)
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