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DOK7 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q18PE1
Clone Names 100405077
Peptide ID 100405077
Additional Information
Gene ID 285489
Other Names Protein Dok-7, Downstream of tyrosine kinase 7, DOK7, C4orf25
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13568a was selected from the N-term region of DOK7. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DOK7
Synonyms C4orf25
Function Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK.
Cellular Location Cell membrane; Peripheral membrane protein. Cell junction, synapse. Note=Accumulates at neuromuscular junctions
Tissue Location Preferentially expressed in skeletal muscle and heart. Present in thigh muscle, diaphragm and heart but not in the liver or spleen (at protein level)
Research Areas
Citations (0)

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The protein encoded by this gene is essential forneuromuscular synaptogenesis. The protein functions in aneuralactivation of muscle-specific receptor kinase, which is requiredfor postsynaptic differentiation, and in the subsequent clusteringof the acetylcholine receptor in myotubes. This protein can alsoinduce autophosphorylation of muscle-specific receptor kinase.Mutations in this gene are a cause of familial limb-girdlemyasthenia autosomal recessive, which is also known as congenitalmyasthenic syndrome type 1B. Alternative splicing results inmultiple transcript variants.


Bergamin, E., et al. Mol. Cell 39(1):100-109(2010)Srour, M., et al. Neuromuscul. Disord. 20(7):453-457(2010)Maselli, R.A., et al. Hum. Mol. Genet. 19(12):2370-2379(2010)Ben Ammar, A., et al. J. Neurol. 257(5):754-766(2010)Vogt, J., et al. J. Med. Genet. 46(5):338-340(2009)

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$ 80.00
Cat# BP13568a
Availability: In Stock
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