|Other Names||Programmed cell death protein 7, ES18, hES18, PDCD7|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13578b was selected from the C-term region of PDCD7. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Promotes apoptosis when overexpressed.|
|Cellular Location||Nucleus. EMBL; AK096970; BAC04915.1; -; mRNA EMBL; AF083930; AAD20241.1; -; mRNA EMBL; BC016992; AAH16992.2; -; mRNA EMBL; BT007395; AAP36059.1; -; mRNA CCDS; CCDS10201.1; - RefSeq; NP_005698.1; NM_005707.1 UniGene; Hs.458596; - ProteinModelPortal; Q8N8D1; - SMR; Q8N8D1; - BioGrid; 115390; 27 IntAct; Q8N8D1; 9 MINT; MINT-1180347; - STRING; 9606.ENSP00000204549; - iPTMnet; Q8N8D1; - PhosphoSitePlus; Q8N8D1; - BioMuta; PDCD7; - DMDM; 38258174; - EPD; Q8N8D1; - MaxQB; Q8N8D1; - PaxDb; Q8N8D1; - PeptideAtlas; Q8N8D1; - PRIDE; Q8N8D1; - DNASU; 10081; - Ensembl; ENST00000204549; ENSP00000204549; ENSG00000090470 GeneID; 10081; - KEGG; hsa:10081; - UCSC; uc002aol.3; human CTD; 10081; - DisGeNET; 10081; - GeneCards; PDCD7; - HGNC; HGNC:8767; PDCD7 HPA; HPA049388; - MIM; 608138; gene neXtProt; NX_Q8N8D1; - OpenTargets; ENSG00000090470; - PharmGKB; PA33117; - eggNOG; ENOG410IVC0; Eukaryota eggNOG; ENOG41124DX; LUCA GeneTree; ENSGT00390000017392; - HOGENOM; HOG000115476; - HOVERGEN; HBG053537; - InParanoid; Q8N8D1; - OMA; PVPQRTH; - OrthoDB; EOG091G0R7S; - PhylomeDB; Q8N8D1; - TreeFam; TF332996; - BioCyc; ZFISH:ENSG00000090470-MONOMER; - Reactome; R-HSA-72165; mRNA Splicing - Minor Pathway ChiTaRS; PDCD7; human GeneWiki; PDCD7; - GenomeRNAi; 10081; - PRO; PR:Q8N8D1; - Proteomes; UP000005640; Chromosome 15 Bgee; ENSG00000090470; - CleanEx; HS_PDCD7; - ExpressionAtlas; Q8N8D1; baseline and differential Genevisible; Q8N8D1; HS GO; GO:0005654; C:nucleoplasm; TAS:Reactome GO; GO:0005689; C:U12-type spliceosomal complex; IDA:HGNC GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW GO; GO:0000398; P:mRNA splicing, via spliceosome; TAS:Reactome GO; GO:0051384; P:response to glucocorticoid; ISS:HGNC GO; GO:0008380; P:RNA splicing; IC:HGNC InterPro; IPR031974; PDCD7 Pfam; PF16021; PDCD7; 1 1: Evidence at protein level; Apoptosis; Coiled coil; Complete proteome; Nucleus; Reference proteome; Repeat CHAIN 1 485 Programmed cell death protein 7 /FTId=PRO_0000058269 COILED 232 335 COILED 362 411 COMPBIAS 4 129 Pro-rich COMPBIAS 236 278 Arg/Glu-rich CONFLICT 292 292 Q -> GE (in Ref. 2; AAD20241) CONFLICT 303 303 S -> A (in Ref. 2; AAD20241) SEQUENCE 485 AA; 54700 MW; FF907D6D2187832A CRC64; MALPPFFGQG RPGPPPPQPP PPAPFGCPPP PLPSPAFPPP LPQRPGPFPG ASAPFLQPPL ALQPRASAEA SRGGGGAGAF YPVPPPPLPP PPPQCRPFPG TDAGERPRPP PPGPGPPWSP RWPEAPPPPA DVLGDAALQR LRDRQWLEAV FGTPRRAGCP VPQRTHAGPS LGEVRARLLR ALRLVRRLRG LSQALREAEA DGAAWVLLYS QTAPLRAELA ERLQPLTQAA YVGEARRRLE RVRRRRLRLR ERAREREAER EAEAARAVER EQEIDRWRVK CVQEVEEKKR EQELKAAADG VLSEVRKKQA DTKRMVDILR ALEKLRKLRK EAAARKGVCP PASADETFTH HLQRLRKLIK KRSELYEAEE RALRVMLEGE QEEERKRELE KKQRKEKEKI LLQKREIESK LFGDPDEFPL AHLLEPFRQY YLQAEHSLPA LIQIRHDWDQ YLVPSDHPKG NFVPQGWVLP PLPSNDIWAT AVKLH|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein with sequence similarity to amouse protein originally identified in embryonic stem cells. Inmouse T-cell lines, this protein appears to be related toglucocorticoid- and staurine-induced apoptotic pathways, and to belinked to ceramide-mediated signalling. These observations suggestthat this gene product is involved in specific apoptotic processesin T-cells.
Colland, F., et al. Genome Res. 14(7):1324-1332(2004)Will, C.L., et al. RNA 10(6):929-941(2004)Park, E.J., et al. Nucleic Acids Res. 27(6):1524-1530(1999)
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