|Other Names||Protein FAN, Factor associated with neutral sphingomyelinase activation, Factor associated with N-SMase activation, NSMAF, FAN|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13585a was selected from the N-term region of NSMAF. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Couples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral sphingomyelinase (N-SMASE). Specifically binds to the N- smase activation domain of TNF-R55. May regulate ceramide production by N-SMASE.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a WD-repeat protein that binds thecytoplasmic sphingomyelinase activation domain of the 55kD tumornecrosis factor receptor. This protein is required for TNF-mediatedactivation of neutral sphingomyelinase and may play a role inregulating TNF-induced cellular responses such as inflammation.Alternative splicing results in multiple transcript variants.
Bailey, S.D., et al. Diabetes Care (2010) In press :Need, A.C., et al. Hum. Mol. Genet. 18(23):4650-4661(2009)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Clarke, C.J., et al. Mol. Pharmacol. 74(4):1022-1032(2008)Kolzer, M., et al. Biol. Chem. 385(12):1193-1195(2004)
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