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NSMAF Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q92636
Clone Names 100406045
Peptide ID 100406045
Additional Information
Gene ID 8439
Other Names Protein FAN, Factor associated with neutral sphingomyelinase activation, Factor associated with N-SMase activation, NSMAF, FAN
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13585a was selected from the N-term region of NSMAF. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms FAN
Function Couples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral sphingomyelinase (N-SMASE). Specifically binds to the N- smase activation domain of TNF-R55. May regulate ceramide production by N-SMASE.
Tissue Location Ubiquitous.
Research Areas
Citations (0)

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This gene encodes a WD-repeat protein that binds thecytoplasmic sphingomyelinase activation domain of the 55kD tumornecrosis factor receptor. This protein is required for TNF-mediatedactivation of neutral sphingomyelinase and may play a role inregulating TNF-induced cellular responses such as inflammation.Alternative splicing results in multiple transcript variants.


Bailey, S.D., et al. Diabetes Care (2010) In press :Need, A.C., et al. Hum. Mol. Genet. 18(23):4650-4661(2009)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Clarke, C.J., et al. Mol. Pharmacol. 74(4):1022-1032(2008)Kolzer, M., et al. Biol. Chem. 385(12):1193-1195(2004)

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$ 80.00
Cat# BP13585a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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