|Other Names||Chondroitin sulfate synthase 1, Chondroitin glucuronyltransferase 1, Chondroitin synthase 1, ChSy-1, Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase 1, N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 1, N-acetylgalactosaminyltransferase 1, CHSY1, CHSY, CSS1, KIAA0990|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13586c was selected from the Center region of CHSY1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||CHSY, CSS1, KIAA0990|
|Function||Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Involved in the negative control of osteogenesis likely through the modulation of NOTCH signaling.|
|Cellular Location||Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein Secreted|
|Tissue Location||Ubiquitous, with the highest levels in placenta. Detected at low levels in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, adrenal gland, mammary gland, stomach, small intestine, lung and peripheral blood leukocytes.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
CHSY1 synthesizes chondroitin sulfate, a glycosaminoglycanexpressed on the surface of most cells and in extracellularmatrices. Glycosaminoglycan chains are covalently linked to a widerange of core protein families and regulate many biologicprocesses, including cell proliferation and recognition,extracellular matrix deposition, and morphogenesis.[supplied byOMIM].
Yada, T., et al. J. Biol. Chem. 278(41):39711-39725(2003)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)Kitagawa, H., et al. J. Biol. Chem. 278(26):23666-23671(2003)Kitagawa, H., et al. J. Biol. Chem. 276(42):38721-38726(2001)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.