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CHSY1 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q86X52 |
|---|---|
| Clone Names | 100406065 |
| Gene ID | 22856 |
|---|---|
| Other Names | Chondroitin sulfate synthase 1, Chondroitin glucuronyltransferase 1, Chondroitin synthase 1, ChSy-1, Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase 1, N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 1, N-acetylgalactosaminyltransferase 1, CHSY1, CHSY, CSS1, KIAA0990 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13586c was selected from the Center region of CHSY1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CHSY1 (HGNC:17198) |
|---|---|
| Synonyms | CHSY, CSS1, KIAA0990 |
| Function | Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP- GalNAc to the non-reducing end of the elongating chondroitin polymer. Involved in the negative control of osteogenesis likely through the modulation of NOTCH signaling. |
| Cellular Location | Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted |
| Tissue Location | Ubiquitous, with the highest levels in placenta. Detected at low levels in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, adrenal gland, mammary gland, stomach, small intestine, lung and peripheral blood leukocytes |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
CHSY1 synthesizes chondroitin sulfate, a glycosaminoglycanexpressed on the surface of most cells and in extracellularmatrices. Glycosaminoglycan chains are covalently linked to a widerange of core protein families and regulate many biologicprocesses, including cell proliferation and recognition,extracellular matrix deposition, and morphogenesis.[supplied byOMIM].
References
Yada, T., et al. J. Biol. Chem. 278(41):39711-39725(2003)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)Kitagawa, H., et al. J. Biol. Chem. 278(26):23666-23671(2003)Kitagawa, H., et al. J. Biol. Chem. 276(42):38721-38726(2001)
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