|Other Names||ADP/ATP translocase 4, ADP, ATP carrier protein 4, Adenine nucleotide translocator 4, ANT 4, Solute carrier family 25 member 31, Sperm flagellar energy carrier protein, SLC25A31, AAC4, ANT4, SFEC|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13592a was selected from the N-term region of SLC25A31. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||AAC4, ANT4, SFEC|
|Function||Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May serve to mediate energy generating and energy consuming processes in the distal flagellum, possibly as a nucleotide shuttle between flagellar glycolysis, protein phosphorylation and mechanisms of motility.|
|Cellular Location||Mitochondrion inner membrane; Multi-pass membrane protein. Cell projection, cilium, flagellum. Note=In sperm flagellum this protein is located in the fibrous sheath, a non-mitochondrial region|
|Tissue Location||Expressed in brain, liver, sperm and testis.|
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Provided below are standard protocols that you may find useful for product applications.
Mitochondrial ADP/ATP carriers, such as SLC25A31, arenuclear-coded mitochondrial proteins that catalyze the exchange ofATP generated in mitochondria by ATP synthase (see MIM 108729)against ADP produced in cytosol by most energy-consuming reactions(Dolce et al., 2005 [PubMed 15670820]).
Gallerne, C., et al. Int. J. Biochem. Cell Biol. 42(5):623-629(2010)Kim, Y.H., et al. Dev. Biol. 302(2):463-476(2007)Dolce, V., et al. FEBS Lett. 579(3):633-637(2005)Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)
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