|Other Names||Zinc transporter 6, ZnT-6, Solute carrier family 30 member 6, SLC30A6, ZNT6|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13600c was selected from the Center region of SLC30A6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Zinc-efflux transporter which allocates the cytoplasmic zinc to the trans-Golgi network (TGN) as well as the vesicular compartment.|
|Cellular Location||Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Found in vesicles|
|Tissue Location||Expressed in brain; especially in cerebellum, hippocampus, parahippocampal gyrus, superior and middle temporal gyrus. Also expressed in B-cells, colon, eye, and lung. Lower expression was present in bone, brain, cervix, ear, heart, kidney, muscle, nerve, pancreas, prostate, skin, stomach, and testis|
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Provided below are standard protocols that you may find useful for product applications.
Zinc functions as a cofactor for numerous enzymes, nuclearfactors, and hormones and as an intra- and intercellular signalion. Members of the zinc transporter (ZNT)/SLC30 subfamily of thecation diffusion facilitator family, such as SLC30A6, permitcellular efflux of zinc (Seve et al., 2004 [PubMed15154973]).
Lyubartseva, G., et al. Brain Pathol. 20(2):343-350(2010)Fukunaka, A., et al. J. Biol. Chem. 284(45):30798-30806(2009)Olsen, J.V., et al. Cell 127(3):635-648(2006)Seve, M., et al. BMC Genomics 5 (1), 32 (2004) :Huang, L., et al. J. Biol. Chem. 277(29):26389-26395(2002)
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