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SAMD4B Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q5PRF9 |
|---|---|
| Clone Names | 100406205 |
| Gene ID | 55095 |
|---|---|
| Other Names | Protein Smaug homolog 2, Smaug 2, hSmaug2, Sterile alpha motif domain-containing protein 4B, SAM domain-containing protein 4B, SAMD4B, SMAUG2 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13601b was selected from the C-term region of SAMD4B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SAMD4B |
|---|---|
| Synonyms | SMAUG2 |
| Function | Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A. |
| Cellular Location | Cytoplasm. Nucleus |
| Tissue Location | Widely expressed in embryonic and adult tissues. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Sterile alpha motif is a widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, it appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine. SAMD4B (Sterile alpha motif domain-containing protein 4B) belongs to the SMAUG family. SAMD4B contains 1 SAM (sterile alpha motif) domain.
References
Bailey, S.D., et al. Diabetes Care (2010) In press :Luo, N., et al. BMB Rep 43(5):355-361(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)
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