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DHRS4 Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9BTZ2
Clone Names 90909040
Peptide ID 90909040
Additional Information
Gene ID 10901
Other Names Dehydrogenase/reductase SDR family member 4, NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase, CR, PHCR, NADPH-dependent retinol dehydrogenase/reductase, NRDR, humNRDR, Peroxisomal short-chain alcohol dehydrogenase, PSCD, SCAD-SRL, Short-chain dehydrogenase/reductase family member 4, DHRS4
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13614c was selected from the Center region of DHRS4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DHRS4
Synonyms SDR25C2
Function Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co- factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity).
Cellular Location Peroxisome. Note=Isoform 1 is peroxisomal, while isoform 4 is not
Tissue Location Isoform 1 is predominantly expressed in normal cervix (at protein level). Isoform 4 is expressed in some neoplastic cervical tissues, but not in normal cervix (at protein level). Isoform 5 and isoform 6 are expressed in a few neoplastic cervical tissues
Research Areas
Citations (0)

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Background

DHRS4 reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity).

References

Su, Z.J., et al. BMC Mol. Biol. 11, 43 (2010) :Persson, B., et al. Chem. Biol. Interact. 178 (1-3), 94-98 (2009) :Zhang, Q., et al. Biosci. Rep. 29(1):47-56(2009)Matsunaga, T., et al. Arch. Biochem. Biophys. 477(2):339-347(2008)Ferreira, M.A., et al. Nat. Genet. 40(9):1056-1058(2008)

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$ 80.00
Cat# BP13614c
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