|Other Names||Potassium channel subfamily K member 18, TWIK-related individual potassium channel, TWIK-related spinal cord potassium channel, KCNK18, TRESK, TRIK|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13619c was selected from the Center region of KCNK18. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. May function as background potassium channel that sets the resting membrane potential. Channel activity is directly activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics, such as isoflurane. Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper. May be involved in the somatosensory function with special respect to pain sensation (By similarity).|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Expressed specifically in dorsal root ganglion and trigeminal ganglion neurons. Detected at low levels in spinal cord.|
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Provided below are standard protocols that you may find useful for product applications.
Two-pore domain potassium channels, such as KCNK18, giverise to background, or leak, potassium conductance, and theyregulate diverse cellular functions by adjusting both the restingmembrane potential and excitability. KCNK18 is unique among thisfamily of potassium channels in that its activity is regulated byintracellular calcium (summary by Czirjak and Enyedi, 2006 [PubMed16569637]).
Lafreniere, R.G., et al. Nat. Med. 16(10):1157-1160(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Egenberger, B., et al. Biochem. Biophys. Res. Commun. 391(2):1262-1267(2010)Pottosin, I.I., et al. Pflugers Arch. 456(6):1037-1048(2008)Czirjak, G., et al. J. Biol. Chem. 283(23):15672-15680(2008)
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