|Other Names||Probable E3 ubiquitin-protein ligase MID2, 632-, Midin-2, Midline defect 2, Midline-2, RING finger protein 60, Tripartite motif-containing protein 1, MID2, FXY2, RNF60, TRIM1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13639b was selected from the C-term region of MID2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||FXY2, RNF60, TRIM1|
|Function||May play a role in microtubule stabilization.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton. Note=Microtubule-associated|
|Tissue Location||Low level in fetal kidney and lung, and in adult prostate, ovary and small intestine|
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The protein encoded by this gene is a member of thetripartite motif (TRIM) family. The TRIM motif includes threezinc-binding domains, a RING, a B-box type 1 and a B-box type 2,and a coiled-coil region. The protein localizes to microtubularstructures in the cytoplasm. Alternate splicing of this generesults in two transcript variants encoding different isoforms.
Lim, J., et al. Cell 125(4):801-814(2006)Jehee, F.S., et al. Am. J. Med. Genet. A 139(3):221-226(2005)Yap, M.W., et al. Proc. Natl. Acad. Sci. U.S.A. 101(29):10786-10791(2004)Short, K.M., et al. BMC Cell Biol. 3, 1 (2002) :Reymond, A., et al. EMBO J. 20(9):2140-2151(2001)
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