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MID2 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9UJV3 |
|---|---|
| Clone Names | 100408304 |
| Gene ID | 11043 |
|---|---|
| Other Names | Probable E3 ubiquitin-protein ligase MID2, 632-, Midin-2, Midline defect 2, Midline-2, RING finger protein 60, Tripartite motif-containing protein 1, MID2, FXY2, RNF60, TRIM1 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13639b was selected from the C-term region of MID2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MID2 |
|---|---|
| Synonyms | FXY2, RNF60, TRIM1 |
| Function | E3 ubiquitin ligase that plays a role in microtubule stabilization. Mediates the 'Lys-48'-linked polyubiquitination of LRRK2 to drive its localization to microtubules and its proteasomal degradation in neurons. This ubiquitination inhibits LRRK2 kinase activation by RAB29 (PubMed:35266954). |
| Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton Note=Microtubule-associated. |
| Tissue Location | Low level in fetal kidney and lung, and in adult prostate, ovary and small intestine |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of thetripartite motif (TRIM) family. The TRIM motif includes threezinc-binding domains, a RING, a B-box type 1 and a B-box type 2,and a coiled-coil region. The protein localizes to microtubularstructures in the cytoplasm. Alternate splicing of this generesults in two transcript variants encoding different isoforms.
References
Lim, J., et al. Cell 125(4):801-814(2006)Jehee, F.S., et al. Am. J. Med. Genet. A 139(3):221-226(2005)Yap, M.W., et al. Proc. Natl. Acad. Sci. U.S.A. 101(29):10786-10791(2004)Short, K.M., et al. BMC Cell Biol. 3, 1 (2002) :Reymond, A., et al. EMBO J. 20(9):2140-2151(2001)
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