|Other Names||E3 ubiquitin-protein ligase TRIM31, 632-, Tripartite motif-containing protein 31, TRIM31, C6orf13, RNF|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13642b was selected from the C-term region of TRIM31. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulator of Src-induced anchorage independent cell growth (By similarity). May have E3 ubiquitin-protein ligase activity.|
|Cellular Location||Cytoplasm. Mitochondrion. Note=Predominantly expressed in the cytoplasm but a fraction is associated with the mitochondria|
|Tissue Location||Up-regulated in gastric adenocarcinomas.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of thetripartite motif (TRIM) family. The TRIM motif includes threezinc-binding domains, a RING, a B-box type 1 and a B-box type 2,and a coiled-coil region. The protein localizes to both thecytoplasm and the nucleus. Its function has not been identified.
Cirulli, E.T., et al. Eur. J. Hum. Genet. 18(7):815-820(2010)Barcellos, L.F., et al. PLoS Genet. 5 (10), E1000696 (2009) :Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)Shiina, T., et al. Genetics 173(3):1555-1570(2006)Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)
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