TRIM31 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9BZY9 |
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Clone Names | 100408317 |
Gene ID | 11074 |
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Other Names | E3 ubiquitin-protein ligase TRIM31, 632-, Tripartite motif-containing protein 31, TRIM31, C6orf13, RNF |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13642b was selected from the C-term region of TRIM31. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TRIM31 {ECO:0000303|PubMed:11331580, ECO:0000312|HGNC:HGNC:16289} |
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Function | E3 ubiquitin-protein ligase that acts as a regulator of antiviral immune response and inflammation by mediating ubiquitination of substrates (PubMed:18773414, PubMed:27929086, PubMed:27992402). Acts as a regulator of innate immune defense against viruses by mediating 'Lys-63'-linked ubiquitination of MAVS, promoting MAVS polymerization and formation of three-stranded helical filaments on mitochondria (PubMed:27992402). Acts as a negative regulator of the NLRP3 inflammasome by catalyzing 'Lys-48'-linked ubiquitination of NLRP3, leading to its degradation (PubMed:27929086). Regulator of Src-induced anchorage independent cell growth (By similarity). |
Cellular Location | Cytoplasm. Mitochondrion. Note=Predominantly expressed in the cytoplasm but a fraction is associated with the mitochondria (PubMed:18773414). Recruited t omitochondria after viral infection (PubMed:27992402). |
Tissue Location | Up-regulated in gastric adenocarcinomas. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of thetripartite motif (TRIM) family. The TRIM motif includes threezinc-binding domains, a RING, a B-box type 1 and a B-box type 2,and a coiled-coil region. The protein localizes to both thecytoplasm and the nucleus. Its function has not been identified.
References
Cirulli, E.T., et al. Eur. J. Hum. Genet. 18(7):815-820(2010)Barcellos, L.F., et al. PLoS Genet. 5 (10), E1000696 (2009) :Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)Shiina, T., et al. Genetics 173(3):1555-1570(2006)Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)
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