|Other Names||Dolichyldiphosphatase 1, Dolichyl pyrophosphate phosphatase 1, DOLPP1, LSFR2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13656b was selected from the C-term region of DOLPP1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate (By similarity).|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
DOLPP1 is required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate (By similarity).
Humphray, S.J., et al. Nature 429(6990):369-374(2004)Rush, J.S., et al. J. Biol. Chem. 277(47):45226-45234(2002)Gilley, J., et al. Hum. Mol. Genet. 8(7):1313-1320(1999)Wedgwood, J.F., et al. J. Biol. Chem. 255(3):1120-1123(1980)
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