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HDAC4 Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P56524
Clone Names 100427093
Peptide ID 100427093
Additional Information
Gene ID 9759
Other Names Histone deacetylase 4, HD4, HDAC4, KIAA0288
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13715b was selected from the C-term region of HDAC4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name HDAC4
Synonyms KIAA0288
Function Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
Cellular Location Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246, Ser-467 and Ser-632 by CaMK4 and SIK1. The nuclear localization probably depends on sumoylation
Tissue Location Ubiquitous.
Research Areas
Citations (0)

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Histones play a critical role in transcriptionalregulation, cell cycle progression, and developmental events.Histone acetylation/deacetylation alters chromosome structure andaffects transcription factor access to DNA. The protein encoded bythis gene belongs to class II of the histone deacetylase/acuc/aphafamily. It possesses histone deacetylase activity and repressestranscription when tethered to a promoter. This protein does notbind DNA directly, but through transcription factors MEF2C andMEF2D. It seems to interact in a multiprotein complex with RbAp48and HDAC3.


Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Williams, S.R., et al. Am. J. Hum. Genet. 87(2):219-228(2010)Kim, T., et al. Psychiatry Res 178(2):266-269(2010)Pan, L., et al. Cell. Mol. Immunol. 7(3):221-226(2010)Smith, J.A., et al. Virol. J. 7, 237 (2010) :

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$ 80.00
Cat# BP13715b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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