|Other Names||Trypsin-2, Anionic trypsinogen, Serine protease 2, Trypsin II, PRSS2, TRY2, TRYP2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13719c was selected from the Center region of PRSS2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||In the ileum, may be involved in defensin processing, including DEFA5.|
|Cellular Location||Secreted, extracellular space.|
|Tissue Location||Expressed in Paneth cells, at the base of small intestinal crypts.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a trypsinogen, which is a member of thetrypsin family of serine proteases. This enzyme is secreted by thepancreas and cleaved to its active form in the small intestine. Itis active on peptide linkages involving the carboxyl group oflysine or arginine. This gene and several other trypsinogen genesare localized to the T cell receptor beta locus on chromosome 7.
Felderbauer, P., et al. Exp. Clin. Endocrinol. Diabetes (2010) In press :Gao, J., et al. Oncol. Rep. 23(6):1683-1692(2010)Cevik, Y., et al. Ulus Travma Acil Cerrahi Derg 16(2):125-129(2010)Andersen, A.M., et al. Pancreas 39(1):26-30(2010)Johansen, D., et al. Pancreatology 10 (2-3), 229-237 (2010) :
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