|Other Names||Histone H1x, H1FX|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13731b was selected from the C-term region of H1FX. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.|
|Cellular Location||Nucleus. Chromosome.|
|Tissue Location||Expressed ubiquitously.|
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Provided below are standard protocols that you may find useful for product applications.
Histones are basic nuclear proteins that are responsiblefor the nucleosome structure of the chromosomal fiber ineukaryotes. Nucleosomes consist of approximately 146 bp of DNAwrapped around a histone octamer composed of pairs of each of thefour core histones (H2A, H2B, H3, and H4). The chromatin fiber isfurther compacted through the interaction of a linker histone, H1,with the DNA between the nucleosomes to form higher order chromatinstructures. This gene encodes a member of the histone H1 family.
Warneboldt, J., et al. BMC Cancer 8, 388 (2008) :Stoldt, S., et al. Biol. Cell 99(10):541-552(2007)Takata, H., et al. FEBS Lett. 581(20):3783-3788(2007)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)
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