|Other Names||Keratin, type II cytoskeletal 6B, Cytokeratin-6B, CK-6B, Keratin-6B, K6B, Type-II keratin Kb10, KRT6B, K6B, KRTL1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13732c was selected from the Center region of KRT6B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Tissue Location||Constitutively expressed in distinct types of epithelia such as those in oral mucosa, esophagus, papillae of tongue and hair follicle outer root sheath|
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The protein encoded by this gene is a member of thekeratin gene family. The type II cytokeratins consist of basic orneutral proteins which are arranged in pairs of heterotypic keratinchains coexpressed during differentiation of simple and stratifiedepithelial tissues. As many as six of this type II cytokeratin(KRT6) have been identified; the multiplicity of the genes isattributed to successive gene duplication events. The genes areexpressed with family members KRT16 and/or KRT17 in the filiformpapillae of the tongue, the stratified epithelial lining of oralmucosa and esophagus, the outer root sheath of hair follicles, andthe glandular epithelia. Mutations in these genes have beenassociated with pachyonychia congenita. The type II cytokeratinsare clustered in a region of chromosome 12q12-q13. [provided byRefSeq].
Millar, E.K., et al. J. Clin. Oncol. 27(28):4701-4708(2009)Schweizer, J., et al. J. Cell Biol. 174(2):169-174(2006)Takahashi, K., et al. J. Biol. Chem. 270(31):18581-18592(1995)Rasmussen, H.H., et al. Electrophoresis 13(12):960-969(1992)Suo, Z., et al. Anticancer Res. 12 (6B), 2025-2031 (1992) :
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