|Other Names||Tumor necrosis factor receptor superfamily member 11B, Osteoclastogenesis inhibitory factor, Osteoprotegerin, TNFRSF11B, OCIF, OPG|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13738c was selected from the Center region of TNFRSF11B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.|
|Tissue Location||Highly expressed in adult lung, heart, kidney, liver, spleen, thymus, prostate, ovary, small intestine, thyroid, lymph node, trachea, adrenal gland, testis, and bone marrow Detected at very low levels in brain, placenta and skeletal muscle. Highly expressed in fetal kidney, liver and lung|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of theTNF-receptor superfamily. This protein is an osteoblast-secreteddecoy receptor that functions as a negative regulator of boneresorption. This protein specifically binds to its ligand,osteoprotegerin ligand, both of which are key extracellularregulators of osteoclast development. Studies of the mousecounterpart also suggest that this protein and its ligand play arole in lymph-node organogenesis and vascular calcification.Alternatively spliced transcript variants of this gene have beenreported, but their full length nature has not been determined.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Liu, J.M., et al. J. Clin. Endocrinol. Metab. 95 (9), E112-E120 (2010) :Lieb, W., et al. Arterioscler. Thromb. Vasc. Biol. 30(9):1849-1854(2010)Paternoster, L., et al. J. Clin. Endocrinol. Metab. 95(8):3940-3948(2010)Hsu, Y.H., et al. PLoS Genet. 6 (6), E1000977 (2010) :
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