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TNFRSF10D Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9UBN6
Clone Names 100427168
Peptide ID 100427168
Additional Information
Other Names Tumor necrosis factor receptor superfamily member 10D, Decoy receptor 2, DcR2, TNF-related apoptosis-inducing ligand receptor 4, TRAIL receptor 4, TRAIL-R4, TRAIL receptor with a truncated death domain, CD264, TNFRSF10D, DCR2, TRAILR4, TRUNDD
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13742b was selected from the C-term region of TNFRSF10D. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TNFRSF10D
Synonyms DCR2, TRAILR4, TRUNDD
Function Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF- kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart EMBL; AF029761; AAD03477.1; -; mRNA EMBL; AF021232; AAC32765.1; -; mRNA EMBL; AF021233; AAC32766.1; -; mRNA EMBL; AF023849; AAC52053.1; -; mRNA EMBL; AY358285; AAQ88652.1; -; mRNA EMBL; AK313528; BAG36307.1; -; mRNA EMBL; BC052270; AAH52270.1; -; mRNA CCDS; CCDS6038.1; - RefSeq; NP_003831.2; NM_003840.4 UniGene; Hs.213467; - ProteinModelPortal; Q9UBN6; - BioGrid; 114321; 6 DIP; DIP-6231N; - IntAct; Q9UBN6; 68 MINT; Q9UBN6; - STRING; 9606.ENSP00000310263; - iPTMnet; Q9UBN6; - PhosphoSitePlus; Q9UBN6; - SwissPalm; Q9UBN6; - BioMuta; TNFRSF10D; - DMDM; 18203495; - EPD; Q9UBN6; - MaxQB; Q9UBN6; - PaxDb; Q9UBN6; - PeptideAtlas; Q9UBN6; - PRIDE; Q9UBN6; - ProteomicsDB; 84018; - DNASU; 8793; - Ensembl; ENST00000312584; ENSP00000310263; ENSG00000173530 GeneID; 8793; - KEGG; hsa:8793; - UCSC; uc003xcz.4; human CTD; 8793; - DisGeNET; 8793; - EuPathDB; HostDB:ENSG00000173530.5; - GeneCards; TNFRSF10D; - H-InvDB; HIX0025539; - HGNC; HGNC:11907; TNFRSF10D HPA; HPA070971; - MIM; 603614; gene neXtProt; NX_Q9UBN6; - PharmGKB; PA36600; - eggNOG; ENOG410IZX0; Eukaryota eggNOG; ENOG4111ZZM; LUCA HOGENOM; HOG000142423; - HOVERGEN; HBG061626; - InParanoid; Q9UBN6; - KO; K22702; - OrthoDB; EOG091G0MOV; - PhylomeDB; Q9UBN6; - TreeFam; TF333916; - Reactome; R-HSA-202733; Cell surface interactions at the vascular wall Reactome; R-HSA-6803211; TP53 Regulates Transcription of Death Receptors and Ligands Reactome; R-HSA-75158; TRAIL signaling SignaLink; Q9UBN6; - SIGNOR; Q9UBN6; - ChiTaRS; TNFRSF10D; human GeneWiki; TNFRSF10D; - GenomeRNAi; 8793; - PRO; PR:Q9UBN6; - Proteomes; UP000005640; Chromosome 8 Bgee; ENSG00000173530; - CleanEx; HS_TNFRSF10D; - Genevisible; Q9UBN6; HS GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central GO; GO:0005886; C:plasma membrane; TAS:Reactome GO; GO:0045569; F:TRAIL binding; IEA:InterPro GO; GO:0004888; F:transmembrane signaling receptor activity; TAS:ProtInc GO; GO:0005031; F:tumor necrosis factor-activated receptor activity; IBA:GO_Central GO; GO:0097190; P:apoptotic signaling pathway; IBA:GO_Central GO; GO:0007166; P:cell surface receptor signaling pathway; TAS:Reactome GO; GO:0006955; P:immune response; IBA:GO_Central GO; GO:0006954; P:inflammatory response; IBA:GO_Central GO; GO:0050900; P:leukocyte migration; TAS:Reactome GO; GO:0007275; P:multicellular organism development; IBA:GO_Central GO; GO:0043066; P:negative regulation of apoptotic process; TAS:ProtInc GO; GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IBA:GO_Central GO; GO:0042981; P:regulation of apoptotic process; TAS:Reactome GO; GO:0042127; P:regulation of cell proliferation; IBA:GO_Central GO; GO:0032496; P:response to lipopolysaccharide; IBA:GO_Central GO; GO:0007165; P:signal transduction; TAS:ProtInc CDD; cd10580; TNFRSF10; 1 InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg InterPro; IPR020465; TNFR_10 InterPro; IPR034024; TNFRSF10_N Pfam; PF00020; TNFR_c6; 2 PRINTS; PR01956; TNFACTORR10 SMART; SM00208; TNFR; 2 PROSITE; PS00652; TNFR_NGFR_1; 2 PROSITE; PS50050; TNFR_NGFR_2; 2 1: Evidence at protein level; Apoptosis; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Membrane; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix SIGNAL 1 55 CHAIN 56 386 Tumor necrosis factor receptor superfamily member 10D /FTId=PRO_0000034584 TOPO_DOM 56 211 Extracellular. TRANSMEM 212 232 Helical. TOPO_DOM 233 386 Cytoplasmic. REPEAT 58 97 TNFR-Cys 1 REPEAT 98 139 TNFR-Cys 2 REPEAT 140 180 TNFR-Cys 3 DOMAIN 340 366 Death; truncated COMPBIAS 225 228 Poly-Val COMPBIAS 246 250 Poly-Gly CARBOHYD 127 127 N-linked (GlcNAc...) asparagine CARBOHYD 182 182 N-linked (GlcNAc...) asparagine DISULFID 83 96 {ECO:0000255|PROSITE-ProRule:PRU00206} DISULFID 99 115 {ECO:0000255|PROSITE-ProRule:PRU00206} DISULFID 118 131 {ECO:0000255|PROSITE-ProRule:PRU00206} DISULFID 121 139 {ECO:0000255|PROSITE-ProRule:PRU00206} DISULFID 141 155 {ECO:0000255|PROSITE-ProRule:PRU00206} DISULFID 158 172 {ECO:0000255|PROSITE-ProRule:PRU00206} DISULFID 162 180 {ECO:0000255|PROSITE-ProRule:PRU00206} VARIANT 35 35 P -> S (in TRAIL-R4-B; dbSNP:rs11135703) /FTId=VAR_011417 VARIANT 276 276 R -> H (in dbSNP:rs55636833) /FTId=VAR_061854 VARIANT 310 310 S -> L (in TRAIL-R4-B; dbSNP:rs1133782) /FTId=VAR_011418 VARIANT 345 345 T -> P (in dbSNP:rs34622674) /FTId=VAR_057288 SEQUENCE 386 AA; 41823 MW; 77A93577CAAF2632 CRC64; MGLWGQSVPT ASSARAGRYP GARTASGTRP WLLDPKILKF VVFIVAVLLP VRVDSATIPR QDEVPQQTVA PQQQRRSLKE EECPAGSHRS EYTGACNPCT EGVDYTIASN NLPSCLLCTV CKSGQTNKSS CTTTRDTVCQ CEKGSFQDKN SPEMCRTCRT GCPRGMVKVS NCTPRSDIKC KNESAASSTG KTPAAEETVT TILGMLASPY HYLIIIVVLV IILAVVVVGF SCRKKFISYL KGICSGGGGG PERVHRVLFR RRSCPSRVPG AEDNARNETL SNRYLQPTQV SEQEIQGQEL AELTGVTVES PEEPQRLLEQ AEAEGCQRRR LLVPVNDADS ADISTLLDAS ATLEEGHAKE TIQDQLVGSE KLFYEEDEAG SATSCL
Research Areas
Citations (0)

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Background

The protein encoded by this gene is a member of theTNF-receptor superfamily. This receptor contains an extracellularTRAIL-binding domain, a transmembrane domain, and a truncatedcytoplamic death domain. This receptor does not induce apoptosis,and has been shown to play an inhibitory role in TRAIL-induced cellapoptosis.

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Pei, G.T., et al. Biochem. Biophys. Res. Commun. 391(2):1274-1279(2010)Lucas, H., et al. J. Dent. Res. 89(1):29-33(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)

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$ 80.00
Cat# BP13742b
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