|Other Names||Tumor necrosis factor receptor superfamily member 10D, Decoy receptor 2, DcR2, TNF-related apoptosis-inducing ligand receptor 4, TRAIL receptor 4, TRAIL-R4, TRAIL receptor with a truncated death domain, CD264, TNFRSF10D, DCR2, TRAILR4, TRUNDD|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13742b was selected from the C-term region of TNFRSF10D. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||DCR2, TRAILR4, TRUNDD|
|Function||Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF- kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of theTNF-receptor superfamily. This receptor contains an extracellularTRAIL-binding domain, a transmembrane domain, and a truncatedcytoplamic death domain. This receptor does not induce apoptosis,and has been shown to play an inhibitory role in TRAIL-induced cellapoptosis.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Pei, G.T., et al. Biochem. Biophys. Res. Commun. 391(2):1274-1279(2010)Lucas, H., et al. J. Dent. Res. 89(1):29-33(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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